Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment ILSI/HESI Research Programme on Alternative Cancer Models: Results of Syrian Hamster Embryo Cell Transformation Assay

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Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment

1. The general advice of the COM when considering the risk assessment of chemicals which are mutagenic in vivo has been that it is prudent to assume a non threshold dose response. Thus it is assumed that any exposure to an in vivo mutagen is associated with some damage to DNA and consequently an increased risk of mutation leading to an increased risk of adverse health effects albeit that this m...

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Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment

3. Blomme et al. (2008) produced a paper of potential relevance to several areas of risk assessment in that it looked at whether a common practice in in vivo studies could introduce errors in the transcriptional dataset. They examined whether serial bleeding could introduce a source of variability in the transcriptomic response of toxicants within affected tissues. Intravenous doses of doxorubi...

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ژورنال

عنوان ژورنال: Toxicologic Pathology

سال: 2002

ISSN: 0192-6233

DOI: 10.1080/01926230213163